The crash happened about 10:20 a.m. near Burbank Boulevard and prompted the closure of three northbound lanes, as well as the northbound transition road to the 101 Freeway, according to the California Highway Patrol.
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The motorcyclist was pronounced dead at the scene, the Los Angeles Fire Department said. His name was not immediately released.
The cause of the incident was unknown.
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Traffic was backed up for miles as a result of the lane shutdown, which the CHP said was expected to last until about 12:45 p.m.