The crash happened just before 5 a.m. in northbound lanes at Exposition Boulevard after someone reported a pedestrian running across lanes, according to the California Highway Patrol.
That person was then struck and killed by a red Dodge Ram, the driver of which stayed at the scene.
All northbound lanes of the freeway were shutdown at one point, but at least two lanes were reopened a short time later.
They were all reopened around 7:30 a.m.