Police said the incident began around 4 a.m. at a business on West Manchester Avenue. The call escalated into a pursuit that ended on the freeway, where the officer-involved shooting occurred.
The suspect's condition and identity have not been released.
The investigation prompted significant traffic disruptions in the area. Authorities diverted vehicles off the freeway at Howard Hughes Parkway, and several northbound on-ramps remained closed.
The freeway will remain closed for at least six hours, according to the CHP.
The investigation is ongoing.
This is a breaking news story. More details will be added as more information becomes available.