The crash was reported shortly before 6 a.m. near the 605 Freeway interchange, according to a California Highway Patrol incident log.
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The collision resulted in a fire that was extinguished by responding firefighters.
The driver of the black Dodge pickup truck was transported to a hospital with major injuries after being found unconscious and trapped inside the vehicle. Several good Samaritans helped extract the injured person, the CHP said.
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Several eastbound lanes were closed as the investigation and cleanup operation got underway. Traffic was backed up as motorists inched past the scene.
The cause of the big rig's stall was under investigation.