The flames erupted around 3 a.m. in an area with several commercial buildings on Main Street, according to the Los Angeles County Fire Department. The 3rd alarm fire quickly spread to the popular Newhall Refinery restaurant and a community theater next door called The MAIN.
It was initially believed that the fire started in the restaurant.
Those familiar with the area were shocked to see the commercial space engulfed in flames.
"It's a shame that this has happened," said Santa Clarita resident Brian Albatche. "Hopefully they rebuild."
Officials say up to six businesses have possibly been impacted, but the exactly extent of the damage has not been determined.
More than 100 hundred firefighters were battling the stubborn blaze that cast an orange glow around the building and sent up thick smoke. The flames were still actively burning some four hours later.
No injuries were reported, and the cause of the fire is under investigation.
DEVELOPING: We will add more details to this report as they become available.