The incident was reported just before 2 a.m. along Firestone Boulevard near Compton Avenue.
A 35-year-old man was found dead the scene. Two other men - a 25-year-old and a 27-year-old - were hospitalized in critical condition.
According to the Los Angeles County Sheriff's Department, one of those men was working as a security guard down the street and was struck by a stray round.
No additional information on the suspect was immediately available.
Anyone with information is being asked to contact LASD's Homicide Bureau at 323-890-5500.