One of the incidents happened just after 1:30 a.m. Friday at The RealReal, a luxury consignment clothing store, on Melrose Avenue in West Hollywood, according to the Los Angeles County Sheriff's Department.
Deputies say multiple suspects wearing black clothing and face coverings crashed their car into the front of the store. Video from the scene shows shattered glass and clothing items strewn across the sidewalk. A red truck was also seen in front of the store, but it's unclear if it was the one used by the suspects.
It's unclear what or how much was taken. No arrests have been made.
This isn't the first such incident this week on Melrose. Earlier this week, four business were hit in the overnight hours.
Meanwhile, Los Angeles police are investigating another smash-and-grab at a 7-Eleven store on Colorado Boulevard in Eagle Rock.
Officers say a truck was used to ram into the store early Friday morning. Several suspects wearing dark clothing who broke in stole an ATM.
Further details were not available. Authorities are investigating both incidents.