The three-car crash was reported just before 6:20 p.m. near Paloma Avenue and Century Boulevard, according to the Los Angeles Fire Department.
Authorities said four children were injured in the crash, including a 12-year-old girl who died at the scene. The three other children were taken to a hospital in moderate condition.
An adult driver was hospitalized in serious condition, while five other adult victims were transported in fair condition.
All transported crash victims are expected to survive, LAPD said.
It's unclear what caused the crash but police believe it may have been due to a car making an unsafe U-turn.