The initial incident, which involved multiple cars, happened around 11:30 p.m. Tuesday near Harbor Boulevard. According to the California Highway Patrol, about seven vehicles were involved in multiple crashes within the same area.
Details about what caused the crashes were not available. A man in his 50s died, authorities said.
All lanes remained closed well into the next morning, snarling the commute for drivers. AIR7 was over the scene where several cars involved in the crash were still strewn across the roadway.
All lanes were reopened just before 9 a.m.