The incident occurred about 2:15 a.m. near the intersection of Broadway and Seventh Street, according to a spokesperson for the Los Angeles Police Department.
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Investigators said the stabbings happened after two groups apparently got into a confrontation that escalated into a fight. Video posted online captured the melee.
The suspect used a knife in the attacks, the LAPD said. He was identified only as a man in his 30s.
The six stabbing victims were transported to L.A. County-USC Medical Center, two in critical condition and four in stable condition, police said. All six were later listed in stable condition and were expected to survive.
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The circumstances that led to the initial confrontation between the two groups was unknown.