The pursuit involved Los Angeles Police Department officers following a vehicle through Hollywood before the driver crashed near the intersection of Fountain Avenue and N. Cherokee Avenue.
Video from the scene showed the suspect on the ground and in handcuffs after what witnesses described as a brief but dangerous chase.
Footage also showed LAPD officers pulling the suspect from an overturned vehicle.
Construction worker Avias Alcantara said he was eating lunch in his truck when the pursuit passed by.
"Everything happened fast ... it was crazy," he said.
According to Alcantara, the suspect's vehicle, followed by numerous police units, crashed into a laundry truck at the intersection before continuing down Cherokee Avenue.
"The car hit the small van, and then they started going on the street and then he hit the fence on the house and roll over," Alcantara said.
Alcantara said the suspect appeared unable to walk after the crash and was removed from the overturned vehicle by officers before being transported by ambulance to a hospital.
The crash occurred in an area where Alcantara said he and other construction workers typically spend their lunch breaks.
"I probably wouldn't be telling this story right now," Alcantara said.
Authorities identified the man taken into custody as a suspect in a Chicago homicide case. Additional details about the homicide investigation and the suspect's condition were not immediately available.