The incident was reported just before 9 p.m. near the intersection of South Mount Vernon Avenue and Centerpointe Drive.
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Police said that when officers arrived, they learned a 1-year-old boy had fallen from a moving vehicle. The child was riding with his parent, according to investigators.
The boy was taken to a local hospital, where he later died.
The Colton Police Department's Major Accident Investigation Team, along with its detective division, is investigating the incident. Police told Eyewitness News on Friday that no one has been arrested or detained.
Anyone who witnessed the crash or has information is asked to contact Cpl. Jonathan Villalobos at 909-370-5000. Information may also be sent by email to jvillalobos@coltonca.gov.