The fire was first reported on the northbound side of the 405 near Ventura Boulevard around 9:40 p.m. Saturday. The freeway was closed between Burbank Boulevard and Skirball Center Driver as fire crews put out the flames.
Video from the scene showed the truck engulfed in flames, which was threatening what was described as 7,600 gallons of diesel fuel, according to the Los Angeles Fire Department.
The driver was able to escape the vehicle.
The fire was extinguished by 10 p.m., though heavy traffic remained on both sides.
No injuries were reported. The cause of the fire was under investigation.