The blaze was reported in the 8300 block of Boer Avenue around 9:14 p.m.
One of the firefighters was injured after they fell through the roof of the home. The firefighter was rushed to a hospital but has since been released.
A second firefighter injured was taken to a hospital as a precaution for possible heat exhaustion, according to the Los Angeles County Fire Department.
It's unclear what caused the fire. No other injuries were reported.