The latest incident occurred Wednesday morning in Willowbrook where a federal agent opened fire during an immigration enforcement operation.
"When you create an atmosphere of mistrust that even if it might have been a legitimate arrest, the neighborhoods don't trust this situation because of what was going on in Minneapolis, but what's been going on here since last June, and it hasn't stopped," Los Angeles Mayor Karen Bass said.
Immigration raids turning violent are not rare in Southern California.
In October, a federal operation in South L.A. left a popular TikToker, Richard Parias, hospitalized with a gunshot wound. Agents said Parias tried to drive into them, but a federal judge later dismissed the charges filed against him.
A week and a half later, Carlos Jimenez - an American citizen - was shot in the shoulder by an Immigration and Customs Enforcement agent in Ontario. ICE said Jimenez tried to hit agents with his car.
Last August, federal immigration officers opened fire on a truck while attempting to arrest a San Bernardino man. His son and son-in-law were also inside. No one was hit, and agents said the driver tried to run them over.
L.A. County Supervisor Holly Mitchell represents the district where the shooting in Willowbrook occurred.
"There is no law enforcement best practice that suggests that you stand in front of a moving vehicle, or you shoot into a moving vehicle," Mitchell said. "It calls into question for me the training, the orientation and the true intent behind these ICE agents."
The state and county have passed laws barring law enforcement officers from hiding their faces in most situations - laws federal agents have mostly ignored.
Meanwhile, the Associated Press published an internal ICE memo that gives its agents permission to forcibly enter homes with just an administrative warrant instead of a judge's warrant.
Legal experts are calling that unconstitutional and say it will be challenged in the courts.