Los Angeles took down Seattle in a 28-12 win before 71,501 fans at the Coliseum, keeping the Rams in the hunt for a playoff spot.
Jared Goff threw for 293 yards and two touchdowns. He also was intercepted twice, including a pick-six that, for a short time, seemed to give Seattle new life.
Todd Gurley II had 23 carries for 79 yards and a touchdown, plus 34 receiving yards.
The Rams defense contained Russell Wilson, keeping him to no touchdowns even as he otherwise stars in what is shaping up as an MVP-caliber season. With 1:25 left in the game, Wilson was picked off in the end zone by Rams cornerback Troy Hill.
The win over a tough NFC West rival gives the 8-5 Rams an added morale boost amid some struggles this season, less than a year after their Super Bowl appearance. In the fight for a wild-card spot, they're just behind the 9-4 Minnesota Vikings.
The Rams' remaining opponents for the season are the Dallas Cowboys, San Francisco 49ers and the Arizona Cardinals.