It happened just after 7:15 p.m. Saturday when deputies were conducting a search of a separate vehicle in a parking lot at Foothill Boulevard and Rochester Avenue in Rancho Cucamonga.
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As the deputy searched the vehicle, the sheriff's department said a driver suddenly drove straight towards him, hitting the vehicle being searched and pinning the deputy.
"The driver of the car got out and came at the deputy, armed with a knife," said the SBCSD in a statement.
At that moment, investigators said a shooting occurred and the armed suspect was struck.
Both the deputy and the suspect were sent to nearby hospitals.
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The deputy suffered injuries to his leg, according to the sheriff's department.
Meanwhile, the suspect's condition is currently unknown.
The incident remains under investigation.