Thirty felony arrests and 12 misdemeanor arrests were made during the sweep, according to a news release from the San Bernardino Police Department. Sixteen firearms, three ounces of methamphetamine, one ounce of cocaine and a large amount of PCP were also seized.
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Two stolen cars were recovered, police said.
The operation was made in response to "increasing criminal gang activity" in San Bernardino.
"Recently, a beautiful, innocent, 8-year-old girl was shot in the face by gang members as she played in front of her home," said San Bernardino Police Chief Darren Goodman.
The news release added that several murders in San Bernardino have been gang-related.
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More than 80 officers with several agencies, including Rialto, Redlands, Fontana, Colton, Montclair and Upland and the San Bernardino County Sheriff's Highland Station were part of the operation.
Police say similar sweeps are planned in the future.