Officers were called at approximately 12:15 a.m. to the Machista Bar at in the 900 block of South Pacific Street, near 10th Street, a Los Angeles Police Department spokeswoman said.
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The incident began when there was an altercation inside the bar, and a woman fired multiple rounds striking three patrons, according to the LAPD.
A man was pronounced dead at the scene. He was not immediately identified.
Paramedics rushed a woman to a hospital in stable condition. Another man was also listed in stable condition after transporting himself to a hospital, police said.
The suspect fled the scene, and police had no detailed description of her.
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Anyone with information about the shooting was urged to call the LAPD's Harbor station at (310) 726-7700. Tipsters who prefer to remain anonymous can call Crime Stoppers at (800) 222-8477, or go to lacrimestoppers.org.