The blaze was first reported around 2 a.m. at a structure in a business park located along the 1500 block of E. McFadden Avenue.
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The fire damaged at least three business units within the structure, which houses offices in the front and warehouses in the back.
Fire officials believe the blaze originated in a business that makes cabinets or furniture.
"The first two businesses look like either a cabinet shop, a lot of wood products, and the third business was, it looked like sewing manufacturing," said a fire battalion chief on scene.
The fire also spread to an adjacent warehouse used by a clothing company that makes flame-retardant shirts.
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Officials believe the cabinet businesses are a complete loss, but official damage estimates were not immediately available.
No one was injured in the blaze. The cause of the fire was under investigation.