The most recent horse death occurred during a training session, prompting track operators to bring in top experts to inspect the track.
"It was a no-brainer. When you have this many issues, you need to take a step back, take a deep breath and get this right," said Mike Willman, an official at Santa Anita Park.
The track was set to host the 82nd Santa Anita Handicap and a qualifier for the Kentucky Derby this weekend.
Track officials are hoping to reschedule the two major races. The Arcadia city manager said the city loses around $5,000 in revenue each day without racing.
Hotels and restaurants surrounding the track are also looking for answers.
"It's going to be a big hit, especially on the weekend for us. I know that after the racing and even before the racing, we get a nice crowd in here," said Genaro Padilla, who was hoping the Villa Catrina Mexican restaurant would cash in on a busy racing weekend.
The park itself is also set to lose out financially.
"I don't have a dollar figure, but it's significant," Willman said. "But again, all that pales in comparison to the issues of safety -- equine and human."