The crash happened around 5:30 p.m. at the intersection of Golden Valley Road and Sierra Highway. Authorities said a truck towing a trailer rear-ended a sedan and that vehicle was pushed into a city bus.
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The driver of the sedan, a woman, was killed in the crash.
"A white truck towing a trailer came up behind the stopped vehicle, collided into it and appeared to push it across the intersection," Sgt. Scott Shoemaker said.
Authorities also said there were five people onboard the bus, including the driver, and only one person suffered minor injuries.
Shoemaker added that the victim's car was smashed after the truck ended up on top of it. The bus also hit power poles near the intersection from the impact of the crash.
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The driver of the bus and truck were taken to a local hospital to be checked for drugs or alcohol, but authorities said they do not believe those substances were factors in the crash.
Authorities also said it was too early in the investigation to say who was at fault.
A SigAlert was issued and the intersection would be closed for the rest of the night, authorities said.
Crews were also working to restore power to the area because the crash affected a nearby electrical pole.
The investigation was ongoing.