The crash happened around 2:20 a.m. near Hayvenhurst Avenue. The semi-truck was involved in a crash with at least six other vehicles, authorities said.
Authorities said at least one person was taken to a nearby hospital. Any other injuries were unknown.
The eastbound lanes were closed until about 4 a.m. when the carpool lane was reopened. All lanes were reopened around 6 a.m.
It was unclear what caused the crash.