The incident occurred along the eastbound 210 Freeway between the Polk Street and Maclay Street exits at approximately 11:30 p.m., police said.
The victim was reportedly on his way to work when two men in a white SUV shot him in the leg.
He was able to exit the freeway and apply a tourniquet to his own leg before calling for help.
Police have not released a description of the shooters nor a possible motive.