One victim was described as unconscious and not breathing at the scene, in the 9100 block of Laurel Canyon Boulevard. The other victim was seen on the ground.
At least one victim appeared to be a male adult.
Paramedics were seen loading both victims onto ambulances.
Witnesses told Eyewitness News they heard about six or seven shots, and then silence.
Los Angeles police said they did not have a description of any possible suspects.