The incident was reported about 4:20 a.m. on the freeway near Crenshaw Boulevard, according to the Los Angeles Police Department and the California Highway Patrol.
The motorist exited the freeway and drove to the area of 17th Street and Gramercy Place in downtown L.A., where the driver is believed to have crashed into a light pole.
Video from the scene showed the frontend of the sedan smashed in. The driver's condition and information on the suspect was not immediately released.
AIR7 HD was over the 10 Freeway around 6:30 a.m. as police cruisers blocked the eastbound lanes while officers combed the area for evidence. All lanes reopened just after 7 a.m.
City News Service contributed to this report.