The shooting happened at Woodman Avenue and Cantara Street near Kaiser Panorama City Medical Center just before 5 p.m. The victims drove themselves to the hospital.
The three male victims were in a pickup truck when they were shot. They were listed in stable condition.
The suspect was last seen driving a black SUV, possibly a Toyota RAV 4 or Honda Pilot, northbound on Woodman.
Police say there is no indication the shooting was gang-related.
DEVELOPING: This story will be updated as more details become available.