The crash happened near Fitzgerald and Erringer roads just before 11:15 p.m., Simi Valley police said.
Officers initially tried to pull over the driver in the silver Lexus for running a red light at the intersection of Sycamore Road and Los Angeles Avenue.
The suspect led police on a chase southbound on Sycamore Road before turning westbound onto Fitzgerald Road.
Police said the 40-year-old man took out a curb and crashed into a utility pole, knocking out power in the area. Debris from a brick wall was seen nearby.
Police said alcohol may have played a part in the crash.
The suspect was transported to a trauma center with major injuries.
Power is being restored in the area.