The collision was reported shortly before 7:30 a.m. at the intersection of Royal Avenue and Vaquero Drive, according to the Simi Valley Police Department.
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The crossing guard suffered "significant" injuries and was transported to a hospital in unknown condition, police Sgt. Steve Shorts said. The vehicle's driver, a man who was not impaired, remained at the scene, the sergeant said.
Traffic at the intersection is regulated by a stoplight, investigators said, but the color of the light at the moment of impact was unclear.
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The age of the pedestrian who was pushed out of the vehicle's path was unknown, but Shorts confirmed the person was not a student.