Los Angeles police said they found two women shot in the lower body and a man shot in the leg near 7th and San Pedro streets at about 7:45 p.m.
Paramedics rushed in to help the three gunshot victims, described as a 45-year-old woman, 30-year-old woman and 30 to 40-year-old man. Their conditions were not immediately known.
The search for a gunman was still underway.
Skid Row is an area where the tents of homeless people line the streets at night.