The flames broke out just before 3 a.m. near San Vincente and Tenaya avenues, according to Los Angeles County fire officials.
Firefighters arrived to find heavy smoke billowing from the one-story home, and the victim was pulled from the house, apparently in cardiac arrest.
First responders attempted to revive the victim as he was transported to a nearby hospital in unknown condition.
The cause of the fire was not immediately known, but fire officials described the home as being in pack-rat condition.