The crash happened at the intersection of East 41st Street and South Central Avenue around 1:50 a.m. on Friday, the LAPD reported.
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According to the department, a 2019 Mercedes-Benz C300 failed to stop at a red light and collided with a 2006 Nissan Altima. The Mercedes driver then abandoned the car and fled on foot.
Paramedics transported the Nissan driver to a hospital with serious injuries, police said.
The LAPD interviewed the registered owner of the Mercedes-Benz who denied driving that night, but it was unclear who was in fact driving.
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Anyone with information on the incident was asked to call the LAPD's Central Traffic Division at 213-833-3713 or the LAPD's 24/7 tipline at 877-527-3247. Tipsters can also call Crime Stoppers at 800-222-8477.