The incident occurred just before 8:30 p.m. near the intersection of W. 95th Street and Normandie Avenue.
Two pedestrians were struck by a vehicle that was seen speeding away from the scene, according to the California Highway Patrol.
One person died at the scene, while the other pedestrian was taken to a local hospital, and later died.
The suspect vehicle was described as a silver pickup truck, and its license plate was left on the street. Authorities are hoping the license plate number will lead them to the driver.
CHP is investigating the incident.
The identity of the victims has not been released.