All lanes of the northbound 110 south of Century Boulevard were closed as authorities investigated the shooting, the California Highway Patrol announced. Lanes reopened just after 6 p.m.
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CHP says the victim crashed into the right shoulder of the freeway and was helped out by a good Samaritan. Authorities later confirmed the victim was shot prior to crashing.
CHP says the shooting was reported just after 3:30 p.m. at the 105 Freeway transition to the 110.
The victim was transported and is in stable condition after being seriously wounded, according to CHP.
A traffic incident log indicated there was an act of "highway violence" at the scene. The motive for the shooting is unclear.
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No suspect or vehicle description was released. The suspect was last seen going north on the 110.
Traffic was diverted onto the 105 Freeway while lanes were closed.