Crews responded to the one-story warehouse near Main Street and Imperial Highway shortly after midnight Wednesday, according to the Los Angeles Fire Department.
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Firefighters were able to knock down the flames in less than an hour, and then they made the deadly discovery. A man was found inside the building and was "beyond medical help," the department said.
He was not immediately identified, and it's unclear whether he died as a result of the fire.
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The cause of the fire is under investigation.