The fire was reported at 12:55 a.m. near the intersection of 51st and S. San Pedro streets.
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Investigators said the blaze broke out in a detached bungalow of the home. It took firefighters about 14 minutes to put the fire out.
The two dogs were found dead inside shortly after, according to the fire department. The five occupants of the home were displaced and receiving assistance with their immediate needs.
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The cause of the fire remains under investigation.