The 26. 2-mile course will take runners from Dodger Stadium, through downtown LA, West Hollywood and Beverly Hills, before ending near the pier in Santa Monica.
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The event is already sold out.
The race begins at 6:30 a.m., but street closures along the course start around 9:30 p.m. Saturday.
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See the complete list of roads closures with projected opening times on the main course, streets open for local access and freeway ramp closures.