The 26. 2-mile course will take runners from Dodger Stadium, through downtown LA, West Hollywood and Beverly Hills, before ending near the pier in Santa Monica.
The event is already sold out.
The race begins at 6:30 a.m., but street closures along the course start around 9:30 p.m. Saturday.
See the complete list of roads closures with projected opening times on the main course, streets open for local access and freeway ramp closures.