Officers responded shortly before midnight to the intersection of 54th Street and Manhattan Place, just west of Western Avenue, the Los Angeles Police Department reported.
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Arriving officers encountered several vehicles and pedestrians dispersing from the area, where they located the victim on the ground suffering from a gunshot wound.
Witnesses told them four men in a vehicle drove up to the victim, stopped and fired several shots at the man, the LAPD said.
Los Angeles Fire Department paramedics were called and pronounced him dead at the scene. His name was not immediately released.
Police created a perimeter near the Western Avenue and 54th Street as they searched for evidence.
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The suspects drove away in an unknown direction. Descriptions of the suspects and their vehicle were not immediately available.
The LAPD's South Bureau Homicide Bureau urged anyone with any information regarding the homicide to call them at (323) 786-5100. Anonymous calls can be made to Crime Stoppers at (800) 222-8477.