Fire officials said the blaze was estimated at just 5 percent containment after burning 12,605 acres as firefighting efforts continued well into the night.
Early Wednesday morning, the California Highway Patrol reopened both sides of the 210 Freeway, though some off-ramps remained closed.
All of the westbound off-ramps from the 2 Freeway to the 5 Freeway remain closed, and four eastbound off-ramps were also closed: Osborne, Wheatland, Sunland and La Tuna Canyon, CHP said.
Approximately 120,000 people were impacted by evacuation orders due to the Creek Fire.
LAFD's evacuation map
Police are monitoring the evacuated neighborhoods to prevent looters.
With the fire moving on from some Sylmar neighborhoods, some residents were lined up in their cars hoping to be allowed back home.
But officials said the evacuation orders would remain because the winds were expected to kick back up again Wednesday night, keeping the fire danger real.
"We want to go home," said Kelly Aquino, who had waited around for hours trying to be allowed back to her house in the Mountain Glen II development. "Right now we're at a hotel. Bottom line is we just want to go home back to our own house, find out what's going on with our properties."
She believes her home was spared from the flames, but did suffer some damage from the winds. Other neighbors down the road at Santiago Estates weren't so lucky, where a number of properties were burned.
More than 800 firefighters from different agencies and more than 50 engines were assisting in the firefight.
RELATED: List of evacuations, closures near Sylmar, Kagel Canyon and surrounding areas
Several firefighters were injured battling the blaze - three were reported to be in stable condition, and at least two were expected to be released from hospitals on Wednesday.
At least 30 structures were destroyed in the blaze, Los Angeles Mayor Eric Garcetti said.
Gov. Jerry Brown also declared an emergency in Los Angeles County for the Creek Fire, as well as the Rye Fire.
The Los Angeles County Fire Department established an information phone line regarding the Creek Fire: (626) 574-5205.