Their age and gender are unknown. According to the Los Angeles Fire Department, both were "transported in at least serious condition" after a vehicle crashed into their bicycle.
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LAFD emergency crews and LAPD officers responded at about 4:30 p.m. to the 13300 block of W. Bombay Street.
Aerial footage from AIR7HD shows a green bicycle, and other items such as clothing and shoes, lying in the middle of the street.
What appears to be a white Jeep is also seen in front of a police patrol car near the crash site, but it's unknown if the vehicle was involved in the collision.
Information on the driver was not available.
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No further details were immediately known.
The cause of the crash is under investigation.