Los Angeles firefighters responded to the 18800 block of Redwing Street around 11:14 p.m. and found the garage with "obvious signs of an explosion," but no active flames.
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A 26-year-old woman and a 52-year-old man suffered burn injuries and were transported to a hospital in critical condition, LAFD said.
Footage from the scene showed debris scatted over the area.
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It's unclear what caused the blast.