The man was identified as 28-year-old Brandyn Rodrigo Mendez of Van Nuys.
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Mendez was gunned down at the Orange Line bus station on Reseda Boulevard and Oxnard Street, according to the LAPD.
Police said Mendez and a second victim got into an argument with the suspect, who pulled out a gun and started shooting multiple times before running away.
1 killed, 1 injured in shooting at Metro bus station in Tarzana, police say
Officers responded to the scene around 7:25 p.m. and found the two wounded victims in the parking lot.
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Mendez later died at a hospital. The other victim is in stable condition, according to police.
No arrest has been made. LAPD is asking for the public's help in identifying the gunman.