The shooting was reported about 10:45 a.m. in the 300 block of 113th Street, just north of Imperial Highway, according to the Los Angeles Police Department.
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An unknown number of suspects drove up in a vehicle and opened fire before fleeing, an LAPD spokesperson said.
Firefighter-paramedics responded to the scene, where the teenager was pronounced dead, authorities said.
Police placed a privacy canopy over the victim's body as the investigation got underway.
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Video from AIR7 HD showed a white compact sedan on the sidewalk with several apparent bullet holes on the passenger side. The rear passenger-side window was shattered.
Nearly two dozen yellow evidence markers were seen on the asphalt in the middle of the street, along with a small pile of shattered glass.
No descriptions of the suspects or their vehicle were available.