The crash was reported in the 27000 block of Sunnyridge Road around 11:30 a.m.
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Authorities say the Tesla driver first hit a utility pole and knocked down power lines. The car then hit another car and wound up against the front of a house.
The driver was pronounced dead at the scene, according to the Los Angeles County Fire Department.
No other injuries were reported.
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It's unknown if the car was on Autopilot, authorities said.
The crash knocked out power to about 100 homes in the area.