Priscilla Ann Salais, 37, was taken into custody Tuesday on two counts of endangering a child, according to KSAT-TV.
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The discovery happened Sunday afternoon, when a woman called 911 asking them for help checking on her grandchildren in a locked bedroom, according to Salais' arrest affidavit.
Firefighters forced their way into the room, and found the children inside. The girl's wrists and ankles were tied, and the bindings were tied together, according to the affidavit. She had visible injuries, including a black eye and bloody lip, according to the arrest affidavit.
The boy was found in a playpen "that was completely covered" by a changing table and baby carrier, trapping the child within the enclosure. The boy's diaper was "heavily soiled," according to the affidavit.
"What she did to these children is unforgivable," Police Chief William McManus said about the arrest on Tuesday.
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Salais was given temporary custody of the children because their parents are being investigated by Child Protective Services due to concerns of physical abuse, according to the affidavit.
While being taken into custody, Salais denied the charges against her, telling reporters they needed to "get their facts straight" about the case.
The children were turned over to CPS.