According to People magazine, Barker is being treated for pancreatitis after complaining of cramps.
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On Tuesday, the 46-year-old was seen being transported by ambulance to Cedars-Sinai Medical Center in Beverly Grove.
His wife, Kourtney Kardashian, was seen by his side in photos.
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Barker tweeted a message Tuesday that read: "God save me." Whether the tweet was related to his medical issue was unclear. The phrase is also the title of a song by his friend Machine Gun Kelly.
Barker's daughter, Alabama, also asked her Instagram followers to send prayers to her father.
The CNN Wire contributed this report.