The university will pay about 18,000 former patients, regardless of whether they've accused Tyndall of misconduct.
Former patients will receive a minimum of $2,500. Those willing to provide further details about their allegations could receive $250,000.
"We are pleased with the Court's decision to order final approval of the federal class action settlement," USC said in a statement. "This settlement provides respectful and confidential relief to Tyndall patients at the student health center and formalizes a broad array of campus reforms."