The crash happened Thursday night in the 6400 block of Woodley Avenue, near Victory Boulevard.
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Aura de la Cruz Calderon de Tobar, 74, and Yeshua Elijah Cordova Tobar were killed when the driver of a white Honda Accord crossed over into oncoming traffic and hit the gray Honda Civic carrying the woman and boy, according to officials.
Investigators say the suspect, who has not been identified, was allegedly driving under the influence.
"I can't see my life without him," said Anna Calderon, the mother of the boy and the woman's daughter. She spoke with Eyewitness News on Wednesday and described seeing her son lying on the street.
She said the family was on their way to dinner. The boy was in the car with his grandmother, who was visiting from El Salvador, along with his stepsister and her boyfriend when the suspect struck their vehicle. The other victims were also injured.
"I'm still asking to God what happened," said the boy's father, Roldan Cordova. "I lost my life. My life is gone with him."
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The boy's mother said Yeshua loved to play soccer and was a fan of the Super Mario brothers. She said he was always happy, full of energy and even graduated preschool recently.
As the collision remains under investigation, a GoFundMe fundraiser has been created for the family as they struggle to comprehend the unimaginable.
"This could have been avoided," said Tiffany Feder, a close family friend. "The burden on this family is incomprehensible, to be driving under the influence, there's no need."