This will be the seventh playoff game under coach Sean McVay, with the Rams going 3-3 in previous postseasons since he was hired in 2017.
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Cardinals quarterback Kyler Murray and head coach Kliff Kingsbury are making their postseason debut at SoFi Stadium.
The two teams split their matchups this season, with the Cardinals winning 37-20 at SoFi and the Rams visiting Arizona to return the favor with a 30-23 victory.
"Really proud of this group, proud of the resilience," McVay said. "I'm looking forward to responding with these guys the right way, and we know it's gonna be a great atmosphere and a really tough game on Monday night against the Cardinals in the playoffs. Here we go!"
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The wild-card playoff game between the Los Angeles Rams and the Arizona Cardinals will air live on ABC at 5:15 p.m. on Monday, Jan. 17.